HSCI 301 Lecture Notes - Lecture 18: Hydrochlorothiazide, Spironolactone, Loop Diuretic
1 Dec 2016
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Excretion = filtration (glomerulus) reabsorption + secretion. Functional zones of nephron: proximal convoluted tubule, loop of henle. Descending: no solute reabsorption but is permeable to water reabsorption (to go back into the blood) Ascending: impermeable to solutes and water reabsorption but can reabsorb 30% na+, k+, and cl- from a co-transport. Cotransporter: protein that helps move 2+ molecules/ions across a membrane in the same direction at the same time. Thiazide diuretics: affects dct, decreases reabsorption of na+ and cl- (inhibits na+/cl- reabsorption cotransporter) Water would normally follow na+ so now you don"t reabsorb as much and end up peeing more out. Loop diuretics antagonizes the na+/k+/2cl- reabsorption cotransporter in ascending limb: inhibits na+, k+ and 2cl- from being reabsorbed (so you pee more out and water will also not be reabsorbed so you pee out more water too) Adverse effects: hypokalemia (potassium depletion) because of a continual loss of k+
