NEUROSCI 101 Lecture Notes - Lecture 16: Depressant, James Olds, Amygdala
5 Apr 2016
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Something that stops dopamine release or absorption inhibit nucleus accumbens: love (but not addicted too) cherries garcia ice cream. More dopamine release if irregular vs reward on a schedule: receptors for dopamine are lower in cocaine addicts. Excess of neurotransmitter tries to modulate this increase, so it reduces the amount of synapses available. Physiological result: reduction in receptor expression ( down-regulate receptor production) Many addictive drugs cause dopamine release in nucleus accumbens. Axons that terminate here originate in ventral tegmental area (vta: involved in reward pathway. Addictive power of drugs may come from stimulating this wanting pathway. Emotion/affect - liking: conscious pleasure, opiates, cannabinoids, cortex regions (ofc, acc, insular, core hedonic pleasures, opiates, cannabinoids, nac shell, ventral pallidum, amygdala. Motivation wanting: conscious, dopamine, cortex regions (ofc, acc, insular) Incentive salience (cue-triggered: dopamine, nac, vta, hypothalamus. Ventral tegmental area effected by all kinds of addictive behaviors: drugs simply co-op/borrow this system to generate an effect.
