MCB 170 Lecture Notes - Lecture 3: Nuclear Membrane, Reverse Transcriptase, Ribavirin
10 Dec 2016
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Document Summary
Virus binds to cell surface molecules to facilitate fusion. Fusion delivers dna and capsid into cytosol. Dna migrates to nucleus and is circularized. Three types of mrna are made (cid:523))e for transcription, e codes the virus"s. Dna is replicated, cleaved, and packaged in pre-assembled capsids. Budding through inner nuclear membrane and fusion with outer nuclear membrane. Neurotropic, alpha-herpesviruses that only infect humans, but they have different genomes. Acute stage is localized (lesions, secretions with virus, spread to nerve endings and ganglia), followed be a period of recovery and latency (virus remains in neurons, lesions heal), and possible recurrent diseases (reactivation, distal spread, localized) Hsv-1 has gg-1 antigens, acute infection in mucoepithelial cells, asymptomatic primary infection, childhood exposure, latency in trigeminal ganglia, cold sore on lips and occurs in 60-70% of adults. Hsv-2 has gg-2 antigens, acute infection in mucoepithelial cells, asymptomatic primary infection, adolescent exposure, latency in sacral ganglia, genital lesions and occurs in 15-30% of sexually active adults.
