DANCEST 805 Lecture Notes - Lecture 4: Motor Control, Inverse Agonist, Latrodectus
Document Summary
Factors influence absorption, distribution, metabolism and excretion of a drug. Pharmacodynamics: drug body: interactions of a drug and the receptors responsible for the action of the drug in the body: neurotransmission, endogenous substances. Steps of neurotransmission: synthesis, storage, release (action potential calcium influx fusing of vesicles, receptor binding, postsynaptic receptor ipsp/epsp, activation of 2nd messenger, presynaptic receptor inhibits further release, deactivation/degradation. 2 categories of receptors: ionotropic receptors fast (epsp or ipsp, metabotropic receptors slow, but longer lasting, auto receptor. Each neurotransmitter has multiple subtypes of receptors: acetylcholine: nicotinic, muscarinic (m1 m5, serotonin: 5-ht (different types, dopamine: d1 d5, noradrenaline: 1, 2 , glutamate : nmda, ampa, mglu, gaba : gabaa, gabab. Receptor agonist: same effects on receptor as neurotransmitter. Inverse agonist: opposite effects on receptors as neurotransmitter: stimulate or inhibit synthesis or release, stimulate or inhibit breakdown or reuptake. Hypothetically: normalization of a deficit: undesirable effects. Disturbances of normal neurotransmission: n. b drugs are distributed through the entire body and brain.