JAPAN 1 Lecture Notes - Lecture 11: Asthma, Impulsivity, Freebase
Document Summary
Inhaling (nitrous oxide aka laughing gas) within seconds, can cause sudden heart and breathing failure and death. Two measures to determine addictiveness of a drug: kinetics, speed of on-/offset, both fast increase in addictiveness, dynamics, measure of efficacy (efficiency of drug when binding to receptors/enzymes), higher efficacy higher addictive potential. Heart can"t pump blood properly), increase in thromboxane production blood clots: regular use: psychosis (with paranoia, delusions, and formication phantom sensation of ants or insects crawling under skin) Injection: necrosis: snorting: ulcers in nose, perforated septum. Effects: blocks dopamine reuptake in the brain increase in dopamine, big increases in dopamine reduction of functioning dopamine receptors . Reduced sense of reward from other activities thus greater dependence on drug. Difference between cocaine and ritalin (e-reader: ritalin acts much like cocaine) Rarely produces high, and no addictive properties: changes when methylphenidate is injected as liquid ( like cocaine ) change in kinetics.
