SOC 32 Lecture Notes - Lecture 34: Central Sulcus, Spinothalamic Tract, Group C Nerve Fiber
Document Summary
Lecture the neurophysiology of pain | 22 -03-2019. Pain: unpleasant sensory and emotional experience associated with actual or potential tissue damage, or described in terms such as damage. Potential of damage is already registered at pain. Nociceptive pain: tissue damage at nociceptors, abeta, adelta and c fibers. If painful stimulus keeps going you have gene transcription, channels are added: triggering nociceptors, afferent c-fibers, afferent adelta fibers. The fibers go up to the dorsal horn = pain gate. In the dorsal horn come the thick and small fibers, will bot activate the interneuron and the pain transmission neuron that goes to the brain. = deregulation of the normal physiological processes in the dorsal horn. Gate selectively open for pain information gate opens more easier. Immediate but transient: activity driven sensitization of pain transmission neurons in the substantia gelatinosa (which mainly involves phosphorylation of ion channels on the postsynaptic membrane)
