BIOE-110 Lecture Notes - Lecture 1: Electrochemical Gradient, Lipid Bilayer, Reaction Rate Constant
12 Feb 2018
School
Department
Course
Professor
Document Summary
Enzymes proteins that catalyze thousands of cellular reactions speeds up chemical reaction but is not consumed allow thermodynamically favorable but kinetically slow reactions to occur does not change dg. Effect of enzymes do not effect dg lower activation energy of reaction by speeding it up change in dg between enzymes transition state and substrate. Dg = dh - tds -- if dg < 0, then the reaction is said to be spontaneous k = rate constant = ae-dgf/rt --- describes kinetics. If dgf decreases, then rate increases --- dg to transition state. Conductive based model describes how action potentials in neurons are initiated/propagated. Voltage-gated ion channel = resistance to ion flow; conductance = 1/r = gn. Concentration gradient = electrochemical gradient, difference in ion concentration inside and outside the cell; voltage sources, en (nernst) Overall membrane potential = vm, arises due to all of the different d[ion] about -65 to -90 mv starting point on action potential curve.
