BISC 464 Lecture Notes - Lecture 1: Endoplasmic Reticulum, Intermediate Filament, Lipofuscin
31 Oct 2017
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The structure and function of the normal cell. Integrated response of the cell to injury i. The colder it is, the better cells survive c. Atrophy, hypertrophy, metaplasia, intracellular accumulations, and aging d. Give rise to residual pigment bodies (lipofuscin) i. Brown pigment composed of oxidized lipids in aging tissue. Consists of microtubules, microfilaments and intermediate filaments i. Glial cells--glial fibrillary acid protein (cause 85% of adult brain cancers) Organ--> tissue--> cell--> molecular events (by cell signaling caused by molecular genetics) Each cell has about 3000 genes on (cell and tissue genes) Cancer causes morphological changes by changing on/off of the cell cycle genes. Tissue--> compensated (reversible cell injury) and decompensated (irreversible cell injury) Epithelial to mesenchymal transition--usually happens in development, but is used by cancer cells to become malignant. Interaction of cells with other cells a. b. Regulated until a point of no return, in which the cell will turn necrotic.
