BIOL 1202 Lecture Notes - Lecture 9: Ernst Boris Chain, Antimetabolite, Clindamycin
Document Summary
The control or the destruction of microorganisms that reside within the bodies of humans and other animals is of tremendous importance. This chapter introduces the principles of chemotherapy and discusses the ideal characteristics for successful chemotherapeutic agents (including the concept of selectively damaging the target microorganism while minimizing damage to the host). The chapter also presents characteristics of some commonly used antibacterial, antifungal, antiviral, and antiprotozoan drugs. Inhibitors of cell wall synthesis are effective and selective because bacterial cell walls have unique structures not found in eukaryotic cells. 2: tetracyclines contain a four-ring structure with side chains; very broad spectrum that includes. Viruses generally use the metabolic machinery of their hosts. Therefore, they should present no selective point of attack for potential antiviral drugs. Yet, recently there have been several antiviral drugs developed that have a reasonably high therapeutic index. Explain: chemotherapeutic agents that are variations of natural biotic products dominate the lists of antimicrobials.
