BIO 203 Lecture Notes - Lecture 9: Unfolded Protein Response, Quality Control, Clathrin
7 Dec 2016
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Lecture #9: chapter 15: intracellular compartments and transport. Aggregation of metabolic enzymes into complexes: both prokaryotic and eukaryotic cells. Segregation of metabolic processes within intracellular compartments: eukaryotic cells. Endoplasmic reticulum (er) synthesis of most lipids; synthesis of proteins for distribution to many. Contains many metabolic pathways; protein synthesis; the cytoskeleton. Golgi apparatus organelles and to the plasma membrane. Modification, sorting, and packaging of proteins and lipids for either secretion or delivery to another organelle. Chloroplasts (in plant cells) atp synthesis and carbon fixation by photosynthesis. Protein sorting: protein sorting, nuclear, endomembrane system, er, golgi, endosomes, lysosomes, transport vesicles, (plasma membrane, mitochondria & chloroplasts, peroxisomes, proteins import into organelles: three mechanisms, 1. Transport through nuclear pores: post translational, uses protein translocators, unfolded proteins, transport across membranes, post-translational into mitochondria and chloroplast, co-translational into er, post-translational, transport by vesicles, pm and rest of endomembrane system, signal sequences defines protein destination. Endosomes: er golgi, golgi apparatus, cis golgi (sorting) medial cisternae (modification) trans.
