BIO_SC 1500 Lecture Notes - Lecture 5: Enzyme Catalysis, Endergonic Reaction, Activation Energy

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16:30: reactions take place when two reactants collide in a certain orientation producing a product (a+bc>ab+c) Activation energy (atp is used) pushes reactants to transition state (reactants reacting) Without activation energy, no product will be formed: atp. Consists of three phosphate groups (four negative charges resulting high potential energy), ribose, and adenine. Energy is released when atp is hydrolyzed (through hydrolysis), atp + When a protein is phosphorylated, the exergonic (more energy is released) phosphorylation reaction is paired with an endergonic (more energy is absorbed) reaction in a process called energetic coupling. In cells, endergonic reactions become exergonic when the substrates or enzymes involved are phosphorylated: catalysis. Bring substrates together in precise orientation so that the electrons involved in the reaction can interact 2. Enzymes are often regulated in the system, they cannot do whatever they want. Competitive inhibition occurs when a molecule similar in size and shape to the substrate blocks the active site.

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