MICROB 3200 Lecture Notes - Lecture 2: Toxic Epidermal Necrolysis, Chromosome, Rifampicin
Document Summary
Describe major classes of antimicrobials and their mechanisms of action. Know the spectra of activitiy of commonly used antibiotics. Understand the mechanisms of microbial resistance to antibiotics. Know the principles of and rationales for antibiotic susceptibility testing. Antibacterial drugs consititute the largest number and diversity of antimicrobial agents. Due to differences in structure and metabolic pathways. Tetracycline ex2. used when you have a wound and there are a variety of pathogens ex3. if you take it orally, it will kill a lot of your friendly bacteria. Used when the host defence mechanisms are impaired. Used when the host defence mechanisms are intact; host cells will kill the bacteria after bacteria is inhibited. Most agents inhibit peptidoglycan synthesis by preventing cross-linkage of. No effect on plan or animal cells (no peptidoglycan) Most prominent in this group are beta-lactam antibiotics: Functional groups are beta-lactam rings (ring with s, n, and cooh) ex.
