BIOM-360 Lecture Notes - Lecture 27: Intramuscular Injection, Aureus, Meninges

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2 May 2018

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Responsible for knowing the organism and the disease process that it causes.

MRSA

Methicillin-Resistant Staph aureus

Need to give to patient either IM (intramuscular) or IV.

Agent, Virulence, Exposure, Dose, Susceptibility

In reality, not all bacteria are pathogenic to humans.

Some have been known for centuries.

Some relatively new.

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Document Summary

Responsible for knowing the organism and the disease process that it causes. Need to give to patient either im (intramuscular) or iv. In reality, not all bacteria are pathogenic to humans. Non-infectious stage of the organism, but it is metabolically active (replicates). Exotoxin inhibits protein synthesis and is responsible for pathogenesis. Composed of dead bac, dead lysed cells that accumulate and sit @ back of throat. Spread by airborne transmission from environmental reservoir to human host. Pontiac fever a little bit more self-contained form of lg disease. Inflammation of the brain or sc meninges (membranes). Can spread from person to person quite easily. Bacteria may be diagnosed by gram stain of csf. Culture of csf may or may not grow bacteria. Clinical manifestations similar to bacterial meningitis but show no microbial agent in gram-stained specimen and in culture. (g+/g- matters!!!)

Related Questions

For this assignment, Part One of your course project, assume the role of Dr. Madness. Your rogue nation seeks global domination. With a bare bones laboratory and your exhaustive microbiological and epidemiological knowledge, you (Dr. Madness) decide that the best way to rule the world is to create and disseminate the perfect biological weapon.

For this part of the assignment, you will develop your weapon from the ground up. Discuss nearly all of the epidemiological criteria related to it, and justify and discuss why it is used and how effective it is. This agent could be a hybrid of other biological pathogens or an entirely new one. If the agent is newly created, there must be some basis and epidemiological support of a similar agent by which you can base your justification. In other words, it will be unrealistic to create an airborne virus that inoculates and kills within one hour. There must be a realistic exposure and incubation time and must be supported through current agent biology or biochemistry (for example, influenza exposure and incubation takes 1â4 days).

Name of Agent: Explain why you chose the name. If it is a biological agent, be sure to provide a taxonomic name

Etiology: This will talk about the genesis of your agent. Where was it discovered? How was it made? How long has it been around? Why was this agent created? What were the social and economic factors of your rogue nation that made Dr. Madness focus on this element of the agent? What are the environmental precursors to this agent? Discuss the interaction among agent, host, and environment.

Identification: This will describe the basics of the agent. Is it a bacteria, virus, toxin, parasite, hybrid, or something else? Discuss how your agent presents within the human population. What are the symptoms in humans? What are the (zoonotic) symptoms in animals? How does the disease progress? Are there stages? Discuss the various stages including length of infection, severity, and the like. What are the diagnostic indicators? How would a doctor be able to identify this agent in a clinic or emergency room?

Laboratory Analysis: How will the agent be identified? Can it be grown in media? What type of laboratory methods can be used to identify the agent (microscopy, chromatography, PCR, and so on)?

Occurrence: This is the epi: who, what, when, where, how, and why of the disease. Where does it happen? When can it be found? Who is most and least susceptible to the agent (risk factors). More exotic and hard to find agents are harder to prevent and control but are also more difficult to initiate an epidemic or pandemic, whereas more generalized and known agents may be easier to cure, but have a much wider swath of causing pandemics. How do socioeconomic factors foster or inhibit the spread of disease?

Reservoir: What is the natural reservoir of the agent? Are there other organisms where this agent can reside without causing disease? Increasing the reservoir can enhance transmission but can also allow for easier identification and treatment in response to it.

Mode of Transmission: Consider inhalation, absorption, digestion, contact, and so forth. If you use multiple modes, justify your selections.

Incubation Period: Provide the range with an average (median) day of disease onset. Does the period change in different socioeconomic status identifiers (sex, age, race, creed, and so on)? Why or why not?

Period of communicability: How long is a person with this agent contagious? Increasing this period also increases the opportunity for study and thus treatment and control.

Susceptibility: Is the agent susceptible to reinfection of the same person? Allowing for this increases morbidity but usually mortality wanes in subsequent infections.

Taking on the role of Dr. Madness, generate your superweapon and describe the weapon using the above mentioned criteria. Remember, the focus in on creating something that becomes difficult to identify, monitor, or treat with prophylaxis. You will write out the proposal as Dr. Madness submitting this to his lead researcher to develop. This proposal should be approximately 6â8 pages in length, but some submissions may be longer.

Submit your Bioweapons and Epidemiology Part One proposal in the assignment area.

Please be sure to review the Bioweapons and Epidemiology Part One Scoring Guide for information on how this assignment is graded.

Project Requirements

To achieve a successful project experience and outcome, you are expected to meet the following requirements.

Written communication: Written communication is free of errors that detract from the overall message.

APA formatting: Resources and citations should be formatted according to current APA style and formatting.

Resources: Include all literature cited in the project.

Length of paper: 6â8 typed, single-spaced pages, not including cover page and resource list.

Font and font size: Arial, 10 point.

Can anyone help me with the following questions, it is due tonight and im having a hard time figuring most of these out and in-between a couple of answers. Thanks!

1. Which of the following is the PRIMARY goal of risk assessment?

A. maximize profit

B. balance risks and benefits

C. reduce liability

D. determine lethal doses

2. The probability of an adverse outcome based on the exposure and potency of a hazardous agent is known as the:

A. toxicity

B. risk

C. hazard

D. margin of safety

E. therapeutic index

3. Risk Assessment includes all the following, except:

A. risk characterization

B. exposure assessment

C. dose-response assessment

D. hazard identification

E. cost-benefit analysis

4. The process of making risk information understood by local officials, community groups and other stakeholders is known as:

A. risk management

B. risk characterization

C. risk communication

D. risk perception

E. risk estimation

5. The Hazard Identification step in the risk assessment paradigm may include which of the following:

A. in vitro testing

B. structure-activity relationships

C. animal bioassays

D. epidemiologic data

E. all of the above

6. A basic premise of carcinogen risk assessment is that:

A. surface area is proportional to body weight

B. chemicals that cause tumors in animals will cause tumors in humans

C. all dosing regimens are equivalent

D. all animal strains are relevant

7. The Point of Departure (POD) for a low-dose extrapolation could be which of the following:

A. NOAEL

B. LOAEL

C. BMDL

D. none of the above

E. all of the above

8. The benchmark dose (BMD) approach is preferred over the NOAEL/LOAEL approach for all the following reasons, except:

A. the full dose-response curve is considered

B. it includes a measure of variability

C. the same benchmark response be used across studies

D. it results in lower reference values

9. A biochemical change, functional impairment, or pathologic lesion affecting an organismâs performance, and reducing its ability to respond to environmental challenges is known in risk assessment as the

A. point of departure

B. benchmark dose

C. adverse effect

D. carcinogenic effect

10. When there is a cancer risk of 1 in 10,000, this is considered to be of

A. high concern

B. moderate concern

C. somewhat low concern

D. no concern at all

11. Which toxicant is commonly found in indoor air due to off-gassing of plywood and furniture?

A. arsenic

B. lead

C. methylene chloride

D. dioxin

E. formaldehyde

12. Which if the following was NOT an event in the United States that triggered widespread awareness of environmental issues in the 1960s?

A. Relocation of families from Love Canal in Niagara Falls, NY

B. Cuyahoga River catching on fire in Ohio

C. Publication of Silent Spring by Rachel Carson

D. Nationwide federal ban of smoking cigarettes in bars and restaurants

13. The study of the fate and effects of chemicals in the environment is the definition of: A. Environmental toxicology

B. Ecotoxicology

C. Environmental health toxicology

D. Risk assessment

14. An example of an area source of air emissions would be:

A. A volcano

B. A moving car

C. A gas station

D. A power plant

15. Which of the following is considered to be âgood up high and bad nearbyâ?

A. Ozone

B. Carbon monoxide

C. Carbon dioxide

D. Sulfur dioxide

16. Which of the following water disinfectants is safest from the perspective of not producing any known DBPs?

A. Chlorine

B. Chloramine

C. Ozone

D. UV

17. The most significant anthropogenic source of carbon monoxide would be classified as a:

A. Point source

B. Area source

C. Mobile source

D. Natural source

18. According to Genius (2006), what do some scientists believe is the most frequent cause of childhood cancer and leukemia?

A. Pharmaceuticals in drinking water

B. Exposure to diuretics in utero

C. Prenatal exposure to carbon monoxide and other industry emissions

D. Neonatal exposure to polyvinylchloride (PVC) plastic

19. In the Genius (2006) article, what did the scientists who published in the journal Science discover about the possible transgenerational impact of exposure to environmental toxicants in pregnancy?

A. Epigenetic mechanisms may permanently alter the germ-line and genetic traits of offspring of an exposed individual

B. Epigenetic changes die out after three successive generations of offspring

C. Epigenetic changes only occur when a toxicant is an endocrine disruptor

D. Epigenetic changes never take place when the toxicant is a pesticide or fungicide

20. According to the article by Chemnick and Climatewire (2013), âSoggy Vancouver Island in British Columbia has become an unlikely new home for Cryptococcus gattii, a tropical and subtropical yeast-based fungus.â What health effect does this yeast-based fungus have on humans when it is inhaled?

A. None

B. Triggers asthma attacks

C. Causes a kind of meningitis

D. Eventually leads to lung cancer

greykangaroo345

Andrea Smith was taking notes for her biology exam. Her professor has told her that the exam would cover, in part, the di erences between sexual and asexual reproduction. As she reviewed her notes and prepared for todayâs class, she was thinking about her own reproductive dilemma. If only asexual reproduction were the case for humans, maybe she wouldnât be in this mess. Or at least there wouldnât be questions about who was the father of her twins. âDwelling on it isnât going to help me prepare for class, and right now I have got to nish this chapter on animal reproduction,â she thought. She tried to concentrate and forget about her current dilemma as she feverishly typed on her notepad:

Asexual or sexual reproduction: 3 types of asexual reproduction: (1) ssion: separation of a parent organism into two or more individuals of equal size, (2) budding: growth of new individuals from outgrowths of existing organisms, and (3) fragmentation accompanied by regeneration: the breaking of the body into several pieces, some or all of which develop into new complete individuals through the regrowth of lost body parts. NOTE: Be able to explain the di erences between sexual and asexual reproduction!

She suddenly let out a long sigh. âItâll be ne,â she thought. âI just hope that none of my family or friends watches the show. What was I thinking when I agreed to this? But thatâs what Xavier wanted, and I will do whatever it takes to prove he is the father. Besides I am going to need the money if I have to take care of these babies on my own!â

e next day in class she was feeling even more nervous and was becoming increasingly angry as she thought about her current situation. Her thoughts were interrupted by the sound of her professorâs voice:

âOK, class,â her teacher was saying, âthat wraps up asexual reproduction. Letâs move on to reproductive cycles
and patterns. Most animals exhibit cycles in their reproductive activity. Reproductive cycles are often controlled
by hormonal and environmental cues. Animals may reproduce either exclusively asexually or sexually while other animals alternate between the two methods. For example, some animals can lay eggs of two types, depending on
the environment and/or season. One egg type matures only if it is fertilized while the other type does not require fertilization for development, a process called parthenogenesis. Some animals, and in rare cases humans, have both male and female reproductive systems. Some hermaphrodites can fertilize themselves, but most must mate with a member of the same species. Please look over these handouts and answer the questions that follow.â

As the other students read through the assignment, Andrea was thinking: âIâm dealing with a case of sexual reproduction that no doubt started with the fertilization of my egg with, hopefully, Xavierâs sperm. at reminds me, I need to make sure I go over internal and external fertilization again in my notes. Iâm not sure I completely understand it.â

All this started the night Xavier had come came over to talk to Andrea about their break-up. He had smelled and looked so good that evening. e events of that night had left Andrea wondering if there was really some truth to that stu about pheromones, which Andrea has learned in her class were chemical signals released by one organism that in uence the behavior of another individual of the same species. Even though Andrea had met someone else and had

âAn Unusual Case of Animal Reproductionâ by Powell and Tillman Page 1

been seeing Neo for a while, she hadnât been able to resist Xavier. Neither she nor Xavier had behaved like themselves that night. It was unlike them not to use some barrier method of contraception. As the class wrapped up, Andreaâs mind was still on her upcoming appearance on a daytime talk show. In some ways she was dreading it; but she was determined to prove what she believed she had known all along: at Xavier was the father of her twins.

Questions

1. What is the di erence between asexual and sexual reproduction?
2. List and de ne some types of asexual reproduction. Give one example of each. 3. What is the di erence between parthenogenesis and hermaphroditism?
4. What is the di erence between internal and external fertilization?
5. What is the function of pheromones?

NATIONAL CENTER FOR CASE STUDY TEACHING IN SCIENCE

âAn Unusual Case of Animal Reproductionâ by Powell and Tillman

Page 2

Part II â The Pregnancy

âI canât believe it has come to this! Airing our dirty laundry on national television. I never thought Xavier would let things get so out of hand.â

It was late and Andrea was so upset she couldnât sleep. She tried studying for the upcoming exam, but she couldnât concentrate. She decided to get an early start on packing. She was so angry with Xavier. How could he have left her pregnant and alone, she thought, as she neatly added her new dress to the bag? How could he think that their babies might belong to someone else? She grabbed her journal, about to add it to the bag, but instead sat in her cozy corner chair and began to read:

January 12, 2007

Iâm pregnant with twins! Sometimes itâs still hard to believe because it was so unexpected. I feel like I am about to pop! I know that Xavier is the father of my babies and I canât wait for us to be a family. But he has doubts about it all because he knows that I met someone else during the brief time that we split up. And he wants to be sure that he is the father before we can move on. But what if it is Neo, the new guy I met? ereâs a slight chance but I doubt it. I know the exact time of conception. It was the night Xavier came over to talk about our relationship. It was a little over a week after that night that the pregnancy test detected the increase in HCG. I guess I just missed him so much.

I do regret that Xavier hasnât been around much during the pregnancy. He has missed the development of our babies. In the past months, I have heard the babiesâ heartbeats and felt them moving around. I wish he would come back because itâs obvious that I am pregnant now. Hopefully we can talk through our di erences and get back together before the pregnancy gets di cultâthe frequent urination and back pain my OB/GYN keeps warning me about. I know there is no way he will ever let me go through labor alone. I only pray the contractions are not more than I can bear. Xavier seems committed to the idea of a paternity test. Hopefully it wonât come to that, but if it does, weâre going to a daytime show to gure all this out.â

âWow! at seems like a lifetime ago,â she thought. âNow we have these beautiful twins and we donât seem any closer to becoming the real family I dreamed about. Well this will all be over in a couple of days. I am 110% con dent that the twins belong to Xavier, not Neo. I canât wait to see the look on Xavierâs face and hear him apologize once he sees the results of the paternity test!â

Questions

1. What does Andrea mean by time of conception?
2. How is HCG used to determine pregnancy?
3. List some changes that occur with the fetus/mother during the 1st, 2nd, and 3rd trimesters. 4. What hormones are responsible for inducing and regulating labor?
5. What trimester is Andrea in during this journal entry?

NATIONAL CENTER FOR CASE STUDY TEACHING IN SCIENCE

âAn Unusual Case of Animal Reproductionâ by Powell and Tillman

Page 3

Part III â The Results

Andrea replayed the words over and over again in her mind: âXavier, you ARE the father!â She was ecstatic. Finally, she could breathe, knowing that Xavier was the father of her babies. en she heard what the host had to say next...

âNeo...YOU ARE the father!â
Andrea looked around in disbelief. She heard herself saying, âWhat do you mean? You just said Xavier was the father!

If Xavier is the father, how can he be the father?â she asked as she pointed toward Neo.

âWell, this is a rst, even for our show. But it appears that your twins were fathered by both of these men.â

âI canât believe it. e rst time I do something like this and I end up with twins and two fathers! Not only did I expose myself to potentially deadly STDs, but now I have two children, whom I have no doubt that I will be raising alone, and I have put my school career in jeopardy,â Andrea thought.

She still couldnât believe this was really happening to her. How was it possible that her TWINS have di erent fathers? What were the events that must have happened within her body that could lead to these circumstances? She grabbed her

journal from her bag and ipped back to the entry describing her feelings the day she found out she was having twins:

August 23, 2006

I just came back from another Drâs appointment. Dr. Blossom informed me that I am having two babiesâ twinsâfraternal. I donât know if they are boys or girls yet. One could be a boy and the other a girl. I still canât believe this has happened. Xavier has to be the father. He has to be! I will have to just play the hand I have dealt myself. How stupid was I? I was going to practice abstinence after Xavier and I broke up...and I certainly wasnât planning on meeting and getting involved with Neo! I canât believe that Neo and I didnât use a condom either. And itâs no excuse that we had been drinking. I just got caught up in the moment with Xavierâgoing down memory lane and things got all sentimental. I could have at least thought to use the rhythm method and kept track of when ovulation may occur. is has to be the most irresponsible thing I have ever done! Why did I stop taking my birth control pills anyway? And I have no idea where I put that diaphragm. Undoubtedly, some people will judge me as the type of woman who should have a tubal ligation that would permanently prevent any pregnancy.

Everything hit her at that very second. She closed her journal and just sat there for a moment. Andrea was reminded that she had stopped taking the pill the month before she became pregnant. She remembered that physicians recommend that a woman wait at least one cycle after she stops taking the pill before becoming pregnant because there is a chance that multiple ovulations may occur. Did it have something to with oogenesis? Andrea was so confused she just couldnât keep things straight in her mind. She thought about it for a minute to let it all sink in.

Andrea sat back and thought about the lecture on animal reproduction the week before. She pulled out her lecture notes on the menstrual cycle, the basic foundation of everything that she was going through.

Questions

1. Describe the two types of cycles that occur in female mammals (menstrual vs. estrous).

2. Compare and contrast the sterilization techniques (vasectomy and tubal ligation) and the temporary and reversible methods discussed in the case.

3. What are the functions of GnRH, FSH, LH, estrogen, and progesterone?

4. How can the paternity results be explained? Your answer should consider the amount of time before and after ovulation a woman is at risk for pregnancy and how long sperm can survive in the reproductive tract. Your discussion may include the following terms: ova, oogenesis, and fertilization, etc.

â¢

Image in title block dervied from licensed image Â© CLIPAREA.comâFotolia.com, ID #21458691. Case copyright held by the National Center for Case Study Teaching in Science, University at Bu alo, State University of New York. Originally published December 8, 2011. Please see our usage guidelines, which outline our policy concerning permissible reproduction of this work.

NATIONAL CENTER FOR CASE STUDY TEACHING IN SCIENCE

âAn Unusual Case of Animal Reproductionâ by Powell and Tillman Page 4

Andreaâs Lecture Notes: The Female Reproductive Cycle

(I) e female reproductive cycle involves both the uterus and the ovaries:

Menstrual cycle = uterine cycle
â¢ Refers to the speci c changes that occur in the uterus

Ovarian cycle
â¢ Cyclic events in the ovaries that regulate the menstrual/uterine cycle

(II) Hypothalamus secretes gonadotrophin-releasing hormone (GnRH) which stimulates the anterior pituitary to secretefollicle stimulating hormone (FSH) and luteinizing hormone (LH) into the blood. FSH and LH regulate the ovarian cycle.

~OVARIAN CYCLE:

Folicular Phase

FSH and LH stimulate a follicle to grow

e growing follicle releases estrogen

Ovulation

â¢ An LH surge triggers ovulation

Luteal Phase

LH stimulates ruptured follicle to become corpus luteum

Corpus luteum secretes estrogen and progesterone, which inhibits LH and FSH secretion from the pituitary

Corpus luteum disintegrates

Estrogen and progesterone levels decrease, releasing the inhibitory e ect on the hypothalamus and the

pituitary

FSH and LH are released and a new cycle begins

(III) Ovarian hormones, estrogen and progesterone, regulate the uterine (menstrual) cycle ~UTERINE CYCLE:

Proliferative Phase

â¢ increasing estrogen levels causes the uterine lining (endometrium) to thicken: prepares the uterus for

implantation of the blastocyst

Secretory Phase
â¢ increased levels of estrogen and progesterone following ovulation maintains the endometrium by increasing

blood supply and growth of endometrial glands that secretes nutrients

Menstrual Flow Phase
â¢ decreased levels of estrogen and progesterone cause the uterine arteries to spasm, depriving the endometrium

of blood: endometrium disintegrates, resulting in menstruation

Based on the information in the case study, Animal Reproduction, please answer the following questions.

Andrea is pregnant and is trying to calculate the time of conception.What is time of conception and how is it determined?

What are the functions of GnRH, FSH LH, estrogen and progesterone in pregnancy?

Andrea is having twins but the babies have two different fathers.Explain the difference between fraternal and identical twins.Which are these?How could the babies have different fathers?

BIOM-360 Lecture Notes - Lecture 27: Intramuscular Injection, Aureus, Meninges

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