BIOS 4630 Lecture Notes - Lecture 4: Van Der Waals Force, Steric Effects, Robert Corey
21 Jan 2017
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The peptide (amide) bond: 2 gtp-dipeptide, 1 gtp=1atp, metabolic cost associated with the formation of this peptide bond, c=o-n-h, all proteins have a certain shelf life, some have relatively short lives hours, some days, some for even longer. Most have relatively rapid turnovers: some basal metabolic rate is used to make new protein, oligopeptide- peptide with just 2 amino acids- dipeptide, catalyzed by proteases. Work of linus pauling and robert corey (on peptide bond in oligopeptides 1930s) Planar and rigid structure: studied the structure of peptide bond and found it was planar and rigid. They (cid:449)ouldn"t ha(cid:448)e e(cid:454)pe(cid:272)ted the stru(cid:272)ture to (cid:271)e rigid due to the (cid:271)ond (cid:271)et(cid:449)een the c- Typically, the single bonds have longer lengths and three rotations per atoms around single bond. But they found here there was relatively little rotation. They have determined there are critical amino acids in the leptin that dictate the folding pattern in both human and salmon.
