HED 044 Lecture Notes - Lecture 30: Necrosis, Moe Williams, Interrupt
2 Nov 2020
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Gerontologist l hayflick: separated human cells in laboratory environment: 120 years. No: high fat diet, overeating, rush-hours, drinking, prime news, income taxes, aggravation. Influence on speed at which cells wear out. Genetic- less vulnerable to environmental factors such as dietary fat, stress, sedentary, lifestyle carcinogens. Atom with at least one unpaired electron, highly reactive, usually seeks other electron, highly reactive, ususalyy seeks other electronn to become paired. If antioxidants unavailable: free radicals suddenly multpily, the cell"s functioning disrupted, cell components damaged, cell necrosis. Free radical stress: lipid peroxidation, atherogenic activity, carcinogenic activity. Pro-oxidant effect: cigarette smoke, imbalanced diet, exhaustive exercise, environmental pollutants, psychological , emotional stress. Inflammation a major source of oxidants. Free radicals are present at higher levels in colon patients with ulcerative collitis. Oxidative stress: inadequate dietary intake of antioxidant nutrients, or also chronic conditions as malabsorption syndrome. Cumulative exposure to high levels of glucocorticoids. Exposure to higher omega-6 fatty acids with decline in beta-6 desaturation.
