BIOSC 0715 Lecture Notes - Lecture 5: Peptide, Covalent Bond, Acid Dissociation Constant
4 Oct 2016
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Small + slightly polar may cross (surprisingly some water can get through) Moving the membrane tubule back and forth quickly did not disturb the plasma membrane: demonstrates flexibility. In general, 50% of most membranes are lipid, 50% are protein, there are a few carbohydrates (do not memorize) Of the lipids, 60% phospholipid and 40% cholesterol. Hy h+ + y: h+ denotes a proton that increases acidity. Larger the numerator, stronger the acid: ka=([h+][a-])/[ha] Lower pka, more likely to lose h+ (more acidic) Just look at carboxyl (cooh) on amino acid dissociation slide. *you are not required to use this equation in this class, just understand pka for each ionizable group. If ph value is greater than pka for a group, group will probably have lost h+ Amino acids are joined by condensation reactions forming peptide bonds. Covalent bond between amino group of 1st amino acid and carboxyl group of 2nd amino acid. <100 amino acids = polypeptide, >100 = protein.
