NROSCI 0081 Lecture Notes - Lecture 23: Hypothalamus, Antiemetic, Basal Ganglia
Document Summary
History: hemp based textiles, chinese pharmacopeia, expansion in america as anti-convulsant and appetite stimulant, i(cid:374)(cid:272)reased use a(cid:374)d regulatio(cid:374)s i(cid:374) (cid:1005)95(cid:1004)"s a(cid:374)d (cid:1005)97(cid:1004)"s, illegal in 1970 in comprehensive drug abuse prevention and. Anti anxiety, anti psychotic, anti inflammatory: cannabinol, thc major psychoactive component of marijuana. Pharmaceutical uses: some are natural extracts from plant, some are synthesized, sativex oral spray from plant; treats ms and cancer-related pain. Not approved in usa may be unstable: synthetic more stable; less likely to break down. Marinol schedule iii drug; approved for anorexia in aids and nausea; synthetic thc. Cesamet schedule ii drug; similar to thc. Smoked: 1-5 minutes, 30-60 minutes for peak effects, depth and duration in lungs affects amount absorbed. Vaporized: heats cannabinoids to boiling point so vapors can be inhaled, lower temp than tars and other carcinogens, distribution. Cannabinoids distribute to areas with high blood flow. Highest in lungs, kidney, and liver bile: metabolism.
