NROSCI 0081 Lecture Notes - Lecture 6: Neuroglia, Reuptake, Membrane Protein
Document Summary
Postsynaptic neuron: receives signal; nt binds postsynaptic receptors. Excitatory: opens ion channel; changes charge to be more positive inside the post synaptic neuron; creates depolarization; epsp more likely to fire action potential. Inhibitory: opens ion channel and changes charge to be more negative inside the post synaptic neuron; creates hyperpolarization; ipsp. Epsps and ipsps vary in magnitude; depend on how much of a nt is released; decremental: summation adding of signals at the hillock if there is enough to reach the threshold, ap will fire. Ap triggers release from vesicle into the synapse: ap reaches terminal, voltage gated ca channels open, ca enters neuron terminal, nt vesicles dock at plasma membrane along synapse of terminal, nt is released into the synapse. Once released into synapse, they bind with receptors: whether it is epsp or ipsp depends on receptors. Ionotropic: embedded membrane protein with two parts; binding site.
