PSY 0505 Lecture Notes - Lecture 29: Homeostasis, Serotonin Receptor Agonist, Dexfenfluramine
Document Summary
Similar effects seen in humans: fenfluramine and dexfenfluramine - over the counter drugs for diet pills work by serotonin agonists people report same effects as mice. Works by serotoin has inhibitory effect on npy (neuropeptide y) receptors. Premise = most people attribute motivation to eat with the prescense of an energty deficit belief that we eat to bring our energy resources back up to an optimal level to an energy point. Hunger waxes and wanes as a function of blood glucose levels. Sophalic phase trigger can release lot of insulin which lowers glucose levels ] Problem with this model is that glucose drops arent cyclical. Amount of fat that we have in cells. A decrease in fat bc of metabolism is what determines when we feel hungry. Measure levels of triglycerides, there is not a big change over the day. Faulty at explaining daily hunger cycles but it can explain longer term (weeks/months) loss in appetite.
