BMS 301 Lecture Notes - Lecture 32: Performance-Enhancing Substance, Central Nervous System, Skeletal Muscle
3 May 2019
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Increase force output for low-frequency electrical stimulation before and after muscle fatigue: may release more ca from sr and/or increase troponin"s, mobilization of fat and glucose major reason for increase in performance binding affinity for ca. Insomnia, diarrhea, anxiety, irritability: -2 adrenergic agonists (clenbuterol, sympathomimetic, designed to treat airway diseases (asthma, animal studies (powerful anabolic agent) Injected into muscles: converted type i type ii muscle fibres, significant increase in muscle mass (especially type ii, enhances lipolysis. Increase risk of aortic ruptures and fractures: human trials (two major studies) Inhaled agonists had no effect on performance: benefits seen if ingested or injected, buffering solutions, exercise causes a decrease in intramuscular ph. Increase in [h+: lactic acid production, a decrease ph leads. Inhibits energy transfer: decrease muscle force development, bicarbonate naturally helps to buffer the [h+] and prevents a decrease in ph, blood buffers endurance performance.
