01:119:115 Lecture Notes - Lecture 15: Neurospora Crassa, Francis Crick, Methyl Group
24 Dec 2015
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Gene expression- the process by which dna directs the synthesis of proteins (and sometimes rna: introduction, history, archibald garrod (1902, studied inherited diseases inborn. Mold has pathway to make all the other nutrients molecules needed. =nutritional mutants: bombarded bread mold with x-rays, mutants unable to produce particular enzyme, one gene one enzyme hypothesis [fig 17. 2] Genes provide instructions for producing a specific protein: one gene one protein (polypeptide) hypothesis, flow of genetic information [fig 17. 3, central dogma of molecular biology, proposed by francis crick 1956, unidirectional flow of genetic information. Dna rna protein: transcription process in which the information from the dna is used, translation ribosomes use information from mrna and use it to. Both transcription and translation occur in all organisms (prokaryote, polypeptides synthesize rna to synthesize eukaryotes: rna- nucleic acid. Stranded: ribose hydroxyl (oh-) group at the 2" position (dna doesn"t, uracil- pyrimidine and substitutes for thymine; lacks a methyl group.
