01:119:115 Lecture Notes - Lecture 98: Euchromatin, Start Codon, Acetyl Group

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Tryna with 1st aa binds a ribosome: elongation. Ex. trna 3" uac 5" anticodon mrna 5" aug 3" codon. Covalently links carboxyl group of a. a to 3" end of trna (uses atp) 2 ribosomal subunits proteins + ribosomal rna (rrna) Large subunit has grooves (depressions) where trna attach. A binding site- holds trna that carries the next aa to be added. P binding site trna holding growing polypeptide. 3. initiation factors bring in large subunit forms translation initiation complex elongation: series of repeated cycles adds a 1 amino acid to growing a peptide, peptidyl transferase. Ribosome catalyse is a rrna not a protein. Catalyzes peptide bond between aa in p and a sites. Covalent bond btw a. a. and trna at p site is broken. Only a certain subset of genes are used at any given time. Constitutive genes (= housekeeping genes) encode proteins that are always needed and are constantly transcribed e. g enzymes involved in respiration.

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