01:119:115 Lecture Notes - Lecture 18: Lethal Allele, Cystic Fibrosis, Nondisjunction
13 Jul 2016
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Difficulties in studying human genetics: few offspring. 2: can"t do experimental mating between individuals unethical & illegal! Instead analyze results of mating that have already occurred: Dna sequencing identify order of nucleotides: pedigree analysis. Pedigree = family tree shows inheritance patterns within a family over several generations. Predict inheritance of phenotypic traits that are controlled by genotype at single locus (figure 14. 15a) Dominant or recessive trait? (purple is recessive &white is dominant reason seen in ann and michael daughter carla: recessively inherited disorders. Many genetic disorders are autosomal recessive. Recessive allele codes for malfunctioning protein or no protein at all. Heterozygote = carrier normal phenotype dominant allele makes enough protein. Have disease 2 copies of gene usually born from carrier parents: albinism. Albinism = autosomal recessive disorder lack of pigmentation in skin and hair. Friday, october 31, 2014 (figure 14. 16: cystic fibrosis. Cystic fibrosis = most common lethal genetic disease in the us.
