01:119:116 Lecture Notes - Lecture 26: Thymus, Immunoglobulin A, Immunoglobulin D

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Lecture 26-immunity (43. 2 and 43. 3: adaptive immunity, timing takes a few days to mobilize. Binds to ag receptor (b or t cell) Each b cell and t cell displays specificity for a specific epitope. Aa sequence varies very little among different b cells: variable (v) region. Each is a binding site for an ag. Each receptor has two identical ag-binding sites. Antibodies ( not b cells) do actual defense against pathogen. Fig 43. 10: b cell classes: 5 types of ig based on heavy chain c regions. T cells: ag receptor consists of 2 different types of polypeptide chains: alpha-chain and beta-chain linked by disulfide bridge. Transmembrane region anchors receptor of pm in t cell. V (variable) region at ends of chains single ag- binding site. Fig 43. 11: t cell ag receptors bind only to fragments of ag that are displayed (presented) on surface of host cells.

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