PHR 4111 Lecture Notes - Lecture 16: Hypoproteinemia, Interstitial Nephritis, Inulin
4 Dec 2017
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Document Summary
Water and salt imbalance electrolyte, a. v abnormalities, volume abnormalities. Excess water ingestion with renal failure - peripheral edema. True volume depletion - loss of bv due to gi (like cholera), renal, sweat or bleeding. Heart failure - urine output decline bc pressure in afferent arterioles will decline leading to loss of filtration pressure. Hepatic cirrhosis - problems in the kidney. Causes backing up of blood in the abdomen interfere with flow of blood into kidney and inhibiting filtration. Hypotension - systemic loss in bp leading to renal failure. Nsaids - decline in flow across glomerulus. Bilateral renal artery sclerosis - bright"s disease. Leads to ade on salt water balance, ph, blood-urea nitrogen levels (bun) Occlusion of tubular lumen with cellular debris that forms a cast that increases pressure to offset perfusion pressure. Decreases/abolishes net perfusion pressure, which is a function of bp capsular hydrostatic pressure and blood osmotic pressure.
