PHS 4601 Lecture Notes - Lecture 5: Phenobarbital, Emulsion, Aspirin
5 Dec 2017
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Usp definition: solid bodies of various weights and shapes, adapted for introduction into the rectal, vaginal, or urethral orifice of the human body. They usually melt, soften, or dissolve at body temperature. A suppository may act as protectant or palliative to the local tissue at the point of introduction or as a carrier of therapeutics agents for systemic or local action. ** are supposed to melt/soften/dissolve at body temp so melting point of base should be at or below body temp. **water soluble bases- high mw peg, solids at room temp. Types of suppositories - vary in terms of shapes and weight rectal suppositories: cylindrical or similar shape: 1-2 inch, ~ 2 grams for adults, 1 gram for others. Vaginal suppositories: globular or oviform, ~ 5 grams (much bigger, softer as compared to rectal supp, also called as inserts or pessaries insertion appliance may be used like a tampon!
