HP 127 Lecture Notes - Lecture 33: Bone, Bone Mineral, Kidney Stone Disease
27 Mar 2019
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Very few positive feedback loops in physiology never stops unless you break the chain (labor, birth, autoimmune d. ) Work like a bridge: need both to bear weight. With bracing of trabecular bone, the cortical bone can bear more weight because it distributes the stress of daily. Trabecular: cortical can thin, but when trabecular bone weakens, the bone cannot bear weight or stress because it. Too much or little and electrolyte functions will go awry, musculature especially affected. Cortical vs. trabecular bone: movement can accumulate in specific areas, leading to breakage. Parathyroid detects loss in calcium, releases pth (parathyroid hormone), which has three effects: All works to counteract decrease in calcium: negative feedback loop. Negative feedback loop: the consequence of the feedback loop is to counteract the original trigger of the action also a negative feedback loop for increase in blood calcium. No if you eat salt, you will absorb all of it (if you eat it, you own it)
