HUMBIO 3A Lecture Notes - Lecture 39: Mast Cell, Blastomere, Macrophage

• School: Stanford University
• Department: Human Biology
• Course: HUMBIO 3A
• Professor: Margaret Fuller; Roeland Nusse

Document Summary

Embryonic sc (cells from blastocyst icm) - pluripotent. Hematopoietic sc give rise to lymphoid and myeloid progenitors. Lymphoid give rise to t and b cells; myeloid to macrophages, dendritic cells, mast cells, etc. Mast cells are innate immune cells that release histamine, which makes blood vessels leaky so that it is easier for macrophages and other cells to reach a site of infection. Sc and niche signaling: niche signaling for sc renewal. Active dorsal is high on the ventral side and low on the dorsal side (the dorsal mutant is all dorsalized). Dorsal is a transcriptional activator for twist and sog, and it is a transcriptional repressor for dpp. It binds to the dna regulatory regions for these proteins with varying affinity. The twist regulatory region has low binding affinity for dorsal; sog regulatory region has high binding affinity for dorsal, as does the dpp regulatory region.