BIO 315 Lecture Notes - Lecture 7: Typhoid Fever, Genital Wart, Gastrointestinal Tract
23 Jan 2020
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Lecture #7: microbial mechanisms of pathogenicity, microbial pathogenicity, pathogenicity: the ability to cause disease. Lipid a portion is responsible for causing pathogenicity. Some of these bacteria can cause spores which can cause problems inside us: virulence: the degree of pathogenicity, pathogens must gain access to the host. Herpes has over 100 different strains, many of these have been correlated with cancer. Parenteral route: any non-oral means of injection, deposited directly into tissues when barriers are penetrated, established by punctures, cuts, wounds, hepatitis, hiv, tetanus, and gangrene. Not all microorganisms which enter the body necessarily cause disease: most pathogens have a preferred portal of entry, salmonella typhi (typhoid fever) - swallow, streptococci (pneumonia) - inhaled. 1: bacillus anthracis (anthrax) - multiple portal of entry, numbers of invading microbes. Id50: infectious dose for 50% of a sample population: measures virulence of a microbe. Inhale 10000 to 20000: ld50: lethal dose for 50% of a sample population, measures potency of a toxin.
