Which of the following is TRUE regarding transition state?
A
Option A: All of the above are true.
B
Option B: Transition state analogs bind the substrate not the enzyme
C
Option C: The transition state represents the ES complex.
D
Option D: The transition state can be stabilized by covalent catalysis.
E
Option E: The free energy between the transition state and the reactants must be negative.
Why can histidine NOT act as a base in the lysosome (an organelle where the pH is close to 4.5)?
A
Option A: Histidine would be protonated at pH 4.5.
B
Option B: Histidine has a positive charge at pH 4.5.
C
Option C: Histidine has a side chain pK close to 6.
D
Option D: None of the above is correct.
E
Option E: All of the above are correct
Acid-base catalysis may be accomplished by:
A
Option A: buffer effects
B
Option B: conformational change
C
Option C: active site specificity
D
Option D: charge delocalization
E
Option E: induced strain
Which type of catalysis may be carried out using redistribution of electron density to facilitate the transfer of a proton?
I. proximity
II. acid-base
III. covalent
IV. strain
A
Option A: I
B
Option B: II, IV
C
Option C: II, III
D
Option D: II
E
Option E: III
Which of the following processes would yield and increase in rate?
A
Option A: The rotational motions of the substrates and catalytic groups
B
Option B: None of the above
C
Option C: All of the above
D
Option D: The orientations of the substrates and catalytic groups
E
Option E: The proximity of the reacting groups
The catalytic mechanism of bovine pancreatic RNase A relies upon acid-base catalysis involving the amino acid __________.
A
Option A: lysine
B
Option B: histidine
C
Option C: glutamic acid
D
Option D: aspartic acid
E
Option E: imidazole