BIO 361 Lecture 24: LECTURE 24A BIOCHEM

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Know all the names of compounds and enzymes of the payoff stage. Don"t need to know cofactors, specific mechanisms that generate atp or reducing equivalents (nadh). We are looking to understand how maintenance of normal biological activities is achieved and how a cell that has become commandeer such pathways (cancer). obsessed with unregulated and unrestrained growth is able to. The glycolytic process is highly regulated so that it can rev up to 100 times its normal capabilities. Per molecule, glycolysis makes a lot of energy because the levels of enzymes and their activity can go sky high when appropriate. Gap dehydrogenase is the only source of nadh in the glycolytic pathway. There is a reactive thiol to which glyceraldehyde binds and there is a reduction of nad+ by the thiohemiacetal to give a thioester. Thioester and mixed anhydrides are two of many important high energy intermediates that are capable of phosphorylating adp to make atp.

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