BIO 447 Lecture Notes - Lecture 3: Aromatic Amino Acids, Unified Atomic Mass Unit, Phenylalanine

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21 Dec 2017
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Typical specific immune defense: antigen recognition - lymphocytes synthesize/inserts into membrane a single type of receptor that binds to specific antigen. Ability to distinguish amongst antigens = plasma membrane receptors. Each lymphocyte is specific for 1 type of antigen: can create clones. Helper t cells: combine with antigen activation secrete cytokines that act on b cells and cytotoxic t cells. Often, b cells and cytotoxic t cells cannot function if not stimulated by cytokines from helper t cells: lymphocyte activation = bind antigen to receptor. Binding multiple cycles of cell division: forms many lymphocytes identical to original that can recognize antigen (clonal expansion) Antigen-binding site: variable ends of both light and heavy chains. Antibodies + pathogens bind via weak noncovalent interactions (dipole- dipole, h-bonds) easy dissociation. Lymphocytes have unique genetic process that allows dna to be cleaved, rejoined to form new dna molecules: cutting/rejoining varies from b cell to b cell great diversity.

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