NEU 211 Lecture Notes - Lecture 3: Complex Analysis, Cytosol, Kanal D
18 May 2016
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Although each type of receptor subunit has a different primary structure, there are stretches where different polypeptide chains have similar sequence of amino acids. Nicotinic ach receptor is the most studied transmitter-gated ion: each subunit polypeptide has four separate segments that coil into alpha helices segments are hydrophobic, except glutamate-gated channels. Most other transmitter-gated channels also have the four hydrophobic segments and pentameric complexes. The m2 region of glutamate subunits do not span membrane but rather form hairpin that enterx/exits from inside of membrane. Ampa, nmda, and kainate ampa and nmda mediate the bulk of fast excitatory synaptic transmission in the brain. Ampa receptors coexist with nmda receptors at many synapses in the brain. Permeable to both na+ and k+, but not permeable to ca2: net effect of activating them at normal, negative membrane potentials is to admit na+ ions into the cell depolarization. Follows the activation of ampa channels: inward ionic current through these channels is voltage dependent.
