PSY 315 Lecture Notes - Lecture 3: Barbiturate, Cross-Tolerance, Hydrophile
Document Summary
Administration | different action per way of administration. Oral (voluntary or tubing) slow/not as precise but easy! Absorption | when the concentration of the drug is same at the site of action and the site of administration, the drug is absorbed! Depends on the length of the time to peak blood levels. Drug"s ability to cross biological membrane (semi-permeable) Size (pores), solubility (water/lipid), ionization biological compartments, polarization, ph alkaline vs. acid (ion trapping) Other factors: blood-brain barrier (astrocytes, brain capillaries, placental barrier. Drug forms: solid, liquid, volatile (cocaine is only stable/forms solid with hcl cocaine hydrochloric acid: drug vehicle: carrier substance with least amount of side effects (ex. solvent, body compartments: space enclosed by membrane. Transportation depends on blood, molecule, affinity, circulation, and temperature. Excretion: principle organ = kidney, functional unit = nephron, other: intestines, lungs, skin, accumulation in fat, plasma, cells.
