NRSC 335 Lecture Notes - Lecture 7: Monocular Deprivation, Neural Darwinism, Pyramidal Cell
6 Mar 2017
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Cell death: why do neurons die, neural darwinism, neurons are overproduced, neurons compete for connections with target, those that make stable connections survive, those that do not perish. S urviving cells adjust synaptic connections throughout life of organism. S ynaptic connectivity regulated by neuronal activity: use it or lose it. Fields for removed whiskers shrink: neighboring fields expand, activity-dependent plasticity, o cular dominance columns. C at visual cortical cells normally respond to light from both eyes. P attern disrupted by monocular deprivation: o pen eye takes over. Found fairly remarkable plasticity; sutured eye received very little input and all of the cells shifted to firing input from open eye: monocular deviation. C ells respond to either one or other eye, not both: binocular deprivation has little effect, brain is very plastic, can change in case of the environment or injury. S ummary: neural development is regulated by . Ions and membrane permeability: r esting p otential, na +/k+ pump.
