BIO 185 Lecture 11: Lecture 11
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Protein folding: protein folding is in uenced by the environment. Folding inside of cells: happens for 2 reasons: folding starts co-translationally, chaperones: prevent inappropriate interactions. Structural variation in amino acids (20) x variation in the order and number of amino acids in the polypeptide chain = millions of possible combinations, yielding millions of possible proteins, yielding millions of possible functions. 20 amino acids polypeptide = 10 amino acids long. Sickle cell anemia: sickle-cell disease is caused by a mutation in the beta-hemoglobin gene that changes a charged amino acid, glutamic acid, to valine, a hydrophobic amino acid. The sickle-cell hemoglobin mutation alters what level(s) of protein structure: primary tertiary b, quaternary, primary, tertiary, and quaternary, primary and tertiary structures only. Answer: d: r groups have nothing to do with secondary structure alteration in quaternary structure - aggregate ( ber) Rate at which substrate is converted to product depends in part on concentration of substrate.
