BIOL 4376 Lecture Notes - Lecture 24: Icosahedral Symmetry, Symmetry, Rna Virus
3 Jul 2020
School
Department
Course
Professor
Document Summary
Associated with the flu, not a cold. Via airborne droplets or contact with contaminated hands or surfaces. Influenza attacks mainly the upper respiratory tract. Cough and weakness may persist for 2-4 weeks after. Plugs into a receptor on the surface of the target cell. Functions as a razor - shaves off sialic acid residues so that influenza can leave the cell. Based on 2 proteins on surface of virus. Rna polymerase makes mistakes! (error prone to small changes; change can lead to outbreak) Abrupt, major changes in ha or na. Caused by genetic reassortment between human, swine, or avian influenza viruses. Moa: inhibit uncoating after it enters the cells blocks release of viral rna into cell. Moa: inhibit influenza virus neuraminidase enzyme, preventing the release of viral particles from infected cells. Moa: inhibits endonuclease activity of a selective polymerase acidic (pa) protein, which is required for viral gene transcription, resulting in inhibition of influenza virus replication.
