BIOL 221 Lecture Notes - Lecture 8: Gastric Acid, Stomach, Chymosin

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Chemical digestion produces chyme (ph ~ 2) Digestive processes in the stomach include mixing waves that aid mechanical digestion and help increase mixing between gastric juice and food. Chemical digestion occurs by the action of the hydrochloric acid, pepsin (the activated form of pepsinogen) and rennin. The combination of mechanical and chemical digestion forms acidic chyme with a ph of around 2. Peristaltic movements of the stomach contribute to mixing of the gastric juice and food as well as moving some of the chyme into the small intestine. Absorption is limited to lipid-soluble substances that are able to pass through the mucus layer and cells. These substances include alcohol and aspirin both of which erode the mucus layer and expose the epithelial cells to the acid within the stomach. There are three phases to the control of gastric secretion. The cephalic phase begins before food enters the stomach.

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