BIO 115 Lecture Notes - Lecture 22: Interstitial Lung Disease, Diffusing Capacity, Atopy
Document Summary
Professor coan clinical utility of the diffusing capacity measurement: msk1a,b, msk3a,c. Diffusing capacity basically tells us how well this lung can diffuse gasses under perfect conditions since there is not normally co in the body, it really wants to diffuse in. It will be elevated in conditions with increased hemoglobin and intact ventilation (alveolar hemorrhage, polycythemia) It will be decreased when ventilation does not match perfusion (low v/q) or when there is anemia or lack of functional blood vessels (pe, emphysema, interstitial lung disease) Atopy: body"s predisposition to create ige in response an an environmental antigen. Th2 cells release cytokines il-4 and il-13, which activate b cells. Activated b cells make ige which in turn activates mast cells. Ige-mast cells causing release of histamine, leukotrienes, and more cytokines. Mast cells and th2 cells release il-5, which activates eosinophils (which release more cytokines). All of this produces an early and a late response:
