BSC 310 Lecture Notes - Lecture 33: Lipid Bilayer, Integrase, Rna-Dependent Rna Polymerase
22 Mar 2016
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Document Summary
Some viral genomes replicate using the cell"s dna polymerase while others including t4, use their own (cid:1) The double-stranded dna linear genome of t4 also encodes genes for primases and helicases (cid:1) Circular permutation- individuals within a population that have the same genes but in different orders. Are terminally redundant in that some sequences are duplicated on both ends of the linear genome (cid:1) Bacteria often eliminate invading viruses via crispr and destroy double-stranded dna using restriction endonucleases (enzymes that cleave foreign dna at specific sequences, preventing its replication) (cid:1) Must protect own dna from digestion with these endonucleases through modification (usually methylation of nucleotides) at the specific sequences where the endonuclease would cut (cid:1) (cid:1) (cid:1) Shortly after infection, t4 dna is transcribed and translated to initiate new virion synthesis (cid:1) (cid:1) This process is complete in less than 30 minutes.
