BSC 310 Lecture Notes - Lecture 34: Lambda Phage, Rna-Dependent Rna Polymerase, Symmetry
22 Mar 2016
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Document Summary
Retroviruses contain an rna genome that is replicated via a dna intermediate (cid:1) Retro means backwards and the viruses were named b/c they transfer information from rna to dna using the enzyme reverse transcriptase (cid:1) (cid:1) Enveloped viruses with several enzymes in the virion (reverse transcriptase, integrase, and a retroviral-specific protease) (cid:1) Also contain specific trna molecules for replication and 2 identical ss- Entry into host cell via fusion with host cytoplasmic membrane at specific receptor sites. Removal of envelope at the cytoplasmic membrane. Reverse transcription of 1 ssrna molecule into a ssdna that is reverse transcribed into a linear dsdna molecule and enters the nucleus. Retroviral dna is integrated into host genome. Transcription of retroviral dna, forming viral mrnas and viral genomic rna. Assembly and packaging of 2 ssrna molecules into nucleocapsids in the cytoplasm. Budding of enveloped virions at the cytoplasmic membrane (cid:1) (cid:1) (cid:1) Viruses are present in enormous numbers in every environment on.
