CH 461 Lecture Notes - Lecture 2: Glycerol Kinase, Phosphoenolpyruvic Acid, Hydrolysis
Document Summary
Energy production from triacylglycerols starts with their hydrolysis into free fatty acids lipase, which catalyzes the hydrolysis reaction to release the free fatty acids and glycerol. The fatty acid is carried through the bloodstream by being adsorbed to serum albumin, while the glycerol goes to the liver. In the liver, glycerol can be sent to the and glycerol. In adipose (fat storing) tissue, this hydrolysis is carried out by a cellular glycolytic pathway by the action of two enzymes, glycerol kinase and glycerol 3 phosphate dehydrogenase. Glyceraldehyde 3 phosphate can also be used as a source cycle (tca cycle) intermediates. of glucose or, after conversion to phosphoenolpyruvate, as a source of tricarboxylic acid. In target tissues, fatty acids are broken down through the oxidation pathway that releases 2 carbon units in succession. Its initial oxidation produces eight acetyl coenzyme a (coa) molecules, eight reduced fad molecules, and eight nadh molecules.
