BIO 201LLB Lecture 28: Bio 201 Lecture 28

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Chromosomal microtubules from the mitotic spindle make contact with kinetochore. All the mitotic chromosomes have not made its way to the center. Three types of cytoplasmic mts in the mitotic spindle. Astral mts: emanate from centrosome into cytoplasm to anchor and position the aster (mitotic spindle: dynamic (growing and shrinking) Chromosomal mts: connect from pericentriolar material of centrosome to kinetochores. Polar mts: extend from centrosome to equator but interact with other polar mts instead of chromosomes. Two of the main forces for movements in prometaphase: cargo and rail action of motor proteins on mts to position mitotic chromosomes and poles, polymerization and depolymerization of tubulin to lengthen and shorten mts. From what is sticking out of the microtubules. Tubulin polymerization and depolymerization and mitotic chromosome movements in. What does this do: lengthen and shorten chromosomal spindle fibers. What would happen if you stopped growth of mts: they are dynamic so shrinking will still occur until they"re gone.

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