BSCI 105 Lecture Notes - Lecture 15: Inositol, Skeletal Muscle, Phosphodiesterase
1 Jul 2016
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Sense & respond to environment: can i mate with that. Sense & respond to own state: should i divide. Coordination and cooperation: division of labor (differentiation, organogenesis and growth, cycles and reproduction. Signaling molecules (ligands: released in response to a stimulus, can be any type of molecule. Reception: ligand specific receptors, conformational change. Interactions within cell: ligand stays outside, information passes membrane, triggers internal pathway. Change in gene expression: determined by receiving cell. Different types: transmembrane gated channels, intracellular nuclear receptors, transmembrane g-proteins, transmembrane kinase coupled. 3. ions flow through: ion concentrations change, ions trigger response. * each receptor binds to a different ligand. * all of these receptors have similar structure. * receptor and g-protein are not linked but are nearby. * the receptor protein changes shape so it can now bind to the g-protein. * g-protein changes shape so gdp is released and gtp is bound to it instead- now. * active g-protein now activates another target protein.
