BMB 401 Lecture Notes - Lecture 10: Tetrameric Protein, Myoglobin, Porphyrin

• School: University of Miami
• Department: Biochemistry and Molecular Biology
• Course: BMB 401
• Professor: Farooq

Document Summary

Protein funtion/ oligomeric-tetrameric: differentiate- myoglobin & hemoglobin- list 3 characteristic each as oxygen-binding. Similarities between hemoglobin and myoglobin: both hemoglobin and myoglobin are oxygen-binding globular proteins, both of them contain the oxygen-binding heem as their prosthetic group, both hemoglobin and myoglobin give the red color to the blood and muscles respectively. Hemoglobin: hemoglobin is a red protein which is responsible for transporting oxygen in the blood of vertebrates. __plateau out___at saturating oxygen: degree of saturation of mb in response to o2 [ ] is given by _ y = po2 / (k + po2)_, _k__is the concentration of oxygen (po2) at which _mb_ is half-saturated. [mbo2]__: the fractional saturation of myoglobin with oxygen is__y = po2 / (k + po2 )_, physiological range of blood in po2 is ___30 100 torr____. _f_ in oxyhb , porphyrin ring is nonplanar (deoxyhb)