BMB 401 Lecture Notes - Lecture 18: Phosphoenolpyruvate Carboxykinase, Pyruvate Carboxylase, Pyruvic Acid
3 Jan 2016
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Pka shuts off or inactivates pyruvate kinase by phosphorylation (cid:1) 2. which decreases the conversion of pep to pyruvate, which has the effect of diverting pep to the synthesis of glucose. We switch off pyruvate kinase and now we need to get the. 2. pyruvate that"s there to loop it up back to pep. Nad+ that can go back up to the glyceraldehyde triphosphate dehydrogenase. What happens is that you are constantly making the lactic acid. The other thing is the muscle, vigorously exercising muscle will make excess lactic acid. The lactic acid is always coming to the liver filtered out of the. 5. blood from the muscle and red blood cells. When lactic acid gets to the liver gets reconverted to the pyruvate. You got to get this pyruvate out of the mitochondria to the. 7. cytosol so that it can become pep. Pyruvate carboxylase has a biotin prosthetic group and its biotin dependent.
