BMB 401 Lecture Notes - Lecture 11: Cell Nucleus, Gtpase, Galactose

• School: University of Miami
• Department: Biochemistry and Molecular Biology
• Course: BMB 401
• Professor: Harris Thomas

Document Summary

Reading: lir biochem6th, ch 31(vi: know the components and understand the steps for import of newly translated protein into the various positions of mitochondria. Proteins that are especially target to the mitochondria have a special sequence. When you have a highly basic, positively charged leading sequence here that ribosome translating protein destined for the mitochondria. N-terminal basic sequence that leads to folded matrix proteins. Internal signals from the outside that can go first to disulfides, second to im alpha helices proteins, third to sam to make beta barrels and fourth goes through mim to make alpha helical proteins. When you have multiple sh they can be oxidized the disulfides bond that helps stabilizing by covalent linking. The tom go through the translocase of the inner membrane to a translocase of another im. Instead of being pumped into the matrix, they go through the translocase ends up as alpha helices in the im (they are membrane proteins)