MIC 301 Lecture Notes - Lecture 18: Marburg Virus, Dog Bite, Negri Bodies

• School: University of Miami
• Department: Microbiology and Immunology
• Course: MIC 301
• Professor: Williams Roger

Document Summary

Arenaviruses: 2 circular rna segments that are circular. L strand = - = different polarity of rna. Rhabdoviruses = really important (rabies: single stranded, prototype for replication of all stranded enveloped viruses, bullet shaped and a real killer, dog bites you and virus enters into muscle and doesn"t do much. As it moves to peripheral nerves it begins to climb up to the cns. Farther away from brain the bite, longer it takes to get to brain: clinical features. Negri bodies in cytoplasm of infected cells (very clear cytoplasmic inclusions) and lets you know it is rabies virus can only be seen post-mortem b/c in the brain. Neurological symptoms and once it gets to brain, game over. If before gets to brain, can take vaccine post exposure. Once clinical disease is apparent, kills you (3 exceptions: 8. Rarely causes inflammatory lesions and not apparent until it is too late.