MIC 321 Lecture Notes - Lecture 13: Antigen-Presenting Cell, Pattern Recognition Receptor, Co-Stimulation

• School: University of Miami
• Department: Microbiology and Immunology
• Course: MIC 321
• Professor: Williams Roger

Document Summary

2: innate immune response releases interferons in early response, few days break and the t cells start to work, if not virus then would be macrophages in the graph. 3 lol: poisons are specific that stop specific t cell activation, can now avoid t cell activation when not wanted like in rejection of transplants, understanding components of t cell activation pathways. Understand where and how professional antigen presenting cells (apc) activate naive t-cells. Slide 5 shows dcs get coated in pathogens and go to lymph nodes through lymphatic vessels. Understand that professional apc (unlike other cells presenting antigens) will costimulate (rather than anergize) Costimulatory molecules can communicate with t cells and start true t cell activation so dcs in lymphoid tissues can do this. 9: tcr gets stimulated by expression of cd4 or cd8 on t cell, costimulation needs ability to express b7 on apc and for cd28 to recognize it on the t cell.