BMB 208 Lecture 5: chemistry class notes 2:13

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Chapter 13: building large molecules: condensation and hydrolysis reactions. Carboxylic acids react with bases: whenever a carboxylic acid reacts with a base, one of the products is the conjugate base of the original acid, which is a carboxylate ion. The conjugate base is generally more water soluble than the carboxylic acid. Amidation reaction conditions: at room temperature, combining a carboxylic acid and an amine results in an acid-base reaction, for an amidation reaction to occur, the reaction must be heated above 100 degrees c. Obviously not a very biological way to make amides. Acid anhydrides: acid anhydrides are the product of the condensation reaction of two acid molecules with the elimination of a water molecule, acid anhydrides can be formed from: A carboxylic acid and a phosphoric acid molecule (mixed anhydride) Two or more phosphoric acid molecules: phosphoric acid anhydrides can be used to link other building blocks into a larger unit.

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